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Manchester City goalkeeper Ederson is absent from Pep Guardiola’s squad to face Arsenal on Sunday afternoon.
He played a full part in the Citizens’ victory against Club Brugge in the Champions League in midweek.
Stefan Ortega starts in his place, with veteran goalkeeper Scott Carson on the bench.
Ederson has made 23 appearances in all competitions for City so far this season, but has been hampered by injuries.
Any potential injury to the Brazil international will come as a worry to Guardiola, who has to contend with injuries for a large part of the season.
John Stones, Manuel Akanji and Josko Gvardiol form the heart of the City defence – though the Croatian could be deployed at left-back due to the inclusion of Matheus Nunes.
Ederson has made 23 appearances in all competitions for City so far this season, but has been hampered by injuries
Any potential injury to the Brazil international will come as a worry to Guardiola, who has to contend with injuries for a large part of the season
In midfield, Mateo Kovacic starts alongside captain Bernardo Silva, who is joined in the starting lineup by Savinho, Omar Marmoush, Phil Foden and Erling Haaland.
Arsenal have avoided an injury scare in goal of their own, with David Raya fit to start after missing his side’s visit to Girona in the Champions League.
Myles Lewis-Skelly, Jurrien Timber and William Saliba return in defence.
Declan Rice, Gabriel Martinelli and Kai Havertz also start after coming on as substitutes in midweek.
The Gunners host Manchester City at the Emirates in a resumption of what has developed into a fiery rivalry between Mikel Arteta’s men and his former employers.
During the reverse fixture in September, Leandro Trossard was controversially shown a second yellow card for kicking the ball away at the end of the first half.
Having to defend for 45 minutes against the champions with 10 men, Arsenal held out until the 98th minute, when John Stones scored a last-gasp equaliser.
The corresponding match last season was also not without incident, as Mateo Kovacic escaped a red card for a late tackle on Declan Rice.
In their previous league fixture, Arsenal players were incensed at referee Michael Oliver’s decision to send off Myles Lewis-Skelly for a foul on Matt Doherty
In their previous league fixture, Arsenal players were incensed at referee Michael Oliver’s decision to send off Myles Lewis-Skelly for a foul on Matt Doherty – a decision that was later rescinded on appeal.
Following Lewis-Skelly’s red card, Arsenal were charged with failing to control their players after the youngster’s team-mates protested to referee Michael Oliver.
The FA said in a statement: ‘Arsenal FC has been charged after its players surrounded a match official during their Premier League fixture against Wolverhampton Wanderers FC on Saturday, 25 January.
‘Arsenal FC has until Monday, 3 February, to provide a response.’
Oliver’s decision infuriated Arsenal boss Mikel Arteta and was widely criticised by pundits, with Alan Shearer calling it ‘one of the worst decisions that I’ve seen in a long time’.
