St Helens enjoyed a bright start but Barrow registered the first points of the game as Nicole Stewart bundled over for a try and added the conversion.
Saints responded just before the 30-minute mark as Phoebe Hook sprinted over on the right-hand side but Faye Gaskin’s conversion attempt bounced off the upright.
Hook scored in the right corner for her second try of the game shortly after to given St Helens the lead for the first time in the match at 8-6.
After half-time, Saints increased that lead as Gaskin sent a kick into the Barrow 20 that was picked up by Rachael Woosey who sprinted into space over for a try.
Woosey then found a gap and ran through once again for four more points.
St Helens found a fifth try of the game just before the hour mark, Vicky Whitfield touching down right underneath the posts, and Gaskin converting.
In the final 20 minutes, tries from Jodie Cunningham, Katie Mottershead and Nom Williams extended their points total to 40 and wrapped up a convincing victory.